Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
USERS' SCORE
Good
Based on 88 Reviews
8.1
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
9.5
We aimed to explore the effectiveness of nattokinase, an enzyme with potent fibrinolytic properties, in treating heart attacks. Through our research, we focused on enhancing the production of nattokinase from a newly identified strain of Pseudomonas aeruginosa, referred to as CMSS, which we isolated from cow milk.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Read More
8
We designed a study to explore the effectiveness of nattokinase in treating acute myocardial infarction, a condition often caused by blood clots. Thrombus formation leads to reduced blood flow, and finding effective treatments is critical for improving outcomes in heart attack patients.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Read More
Most Useful Reviews
9
No further heart attacks
293 people found this helpful
I learned about nattokinase after my father was diagnosed with heart problems, having suffered a heart attack. We consulted his physician and switched to natural treatment with nattokinase. After a year, his blood circulation improved, and he hasn't had any further heart attacks. This truly is essential for heart patients.
Read More
9
Combats heart issues
235 people found this helpful
This unique enzyme is crucial for preventing numerous diseases, particularly those related to the heart. It dissolves excess fibrin in blood vessels, improves circulation, and lowers the risk of heart attacks. I personally experienced relief from severe symptoms after taking nattokinase, alongside serrapeptase and arjuna.
Read More
9
No arrhythmia recurrence
180 people found this helpful
This superb drug has supported me for two years following a heart failure and arrhythmia. Switching from Xarelto to nattokinase has been incredibly beneficial, as there have been no arrhythmia recurrences since then.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
- All Researches
9.5
We aimed to explore the effectiveness of nattokinase, an enzyme with potent fibrinolytic properties, in treating heart attacks. Through our research, we focused on enhancing the production of nattokinase from a newly identified strain of Pseudomonas aeruginosa, referred to as CMSS, which we isolated from cow milk.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Read More
8
We designed a study to explore the effectiveness of nattokinase in treating acute myocardial infarction, a condition often caused by blood clots. Thrombus formation leads to reduced blood flow, and finding effective treatments is critical for improving outcomes in heart attack patients.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 88 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
No further heart attacks
293 people found this helpful
I learned about nattokinase after my father was diagnosed with heart problems, having suffered a heart attack. We consulted his physician and switched to natural treatment with nattokinase. After a year, his blood circulation improved, and he hasn't had any further heart attacks. This truly is essential for heart patients.
Read More
9
Combats heart issues
235 people found this helpful
This unique enzyme is crucial for preventing numerous diseases, particularly those related to the heart. It dissolves excess fibrin in blood vessels, improves circulation, and lowers the risk of heart attacks. I personally experienced relief from severe symptoms after taking nattokinase, alongside serrapeptase and arjuna.
Read More
9
No arrhythmia recurrence
180 people found this helpful
This superb drug has supported me for two years following a heart failure and arrhythmia. Switching from Xarelto to nattokinase has been incredibly beneficial, as there have been no arrhythmia recurrences since then.
Read More
9
Blood density management
56 people found this helpful
Nattokinase, widely researched in Asia, is highly valued for its blood clot-dissolving properties. It serves as an effective prevention method against heart attack and cardiovascular diseases, making it the best alternative to aspirin.
Read More
9
Resolved palpitations
24 people found this helpful
After experiencing heart palpitations post-vaccination, I tried Doctors Best Nattokinase. Within three weeks, my palpitations disappeared, which my doctor found astonishing. I continue to take it and recommend this life-saving product to others.
Read More
Frequently Asked Questions
9
Resolved palpitations
24 people found this helpful
After experiencing heart palpitations post-vaccination, I tried Doctors Best Nattokinase. Within three weeks, my palpitations disappeared, which my doctor found astonishing. I continue to take it and recommend this life-saving product to others.
9
No further heart attacks
293 people found this helpful
I learned about nattokinase after my father was diagnosed with heart problems, having suffered a heart attack. We consulted his physician and switched to natural treatment with nattokinase. After a year, his blood circulation improved, and he hasn't had any further heart attacks. This truly is essential for heart patients.
9
Reliable heart aid
2 people found this helpful
I chose Doctor's Best Nattokinase for heart and blood circulation support, and the results have been remarkable. It’s both reliable and effective, with a convenient dosage of one capsule. After a few weeks, I noted an improvement in my health and energy. I recommend it to anyone concerned about heart health.
7.5
Reduced heart attack risk
7 people found this helpful
I used nattokinase for my elderly mother, who had very thick blood and vascular issues. For three months, she took one pill nightly and hasn’t had a heart attack, which previously occurred weekly. She also reports her legs burning less. I will definitely continue this.
9
No arrhythmia recurrence
180 people found this helpful
This superb drug has supported me for two years following a heart failure and arrhythmia. Switching from Xarelto to nattokinase has been incredibly beneficial, as there have been no arrhythmia recurrences since then.
9
Improved breathing
9 people found this helpful
I struggled with CTEPH, which left me breathless. After taking two capsules of Nattokinase daily on an empty stomach, I can now walk for 20 minutes without getting breathless. This supplement has truly transformed my life.
9
Safe blood thinner
6 people found this helpful
My blood pressure is normal and bad cholesterol has decreased since I stopped taking aspirin, which ruined my stomach. After Covid, I had an increase in blood clots. Nattokinase has been a safe remedy, preventing heart attacks while aiding my overall health.
9
Combats heart issues
235 people found this helpful
This unique enzyme is crucial for preventing numerous diseases, particularly those related to the heart. It dissolves excess fibrin in blood vessels, improves circulation, and lowers the risk of heart attacks. I personally experienced relief from severe symptoms after taking nattokinase, alongside serrapeptase and arjuna.
9
Improved health post-covid
8 people found this helpful
I cannot recommend this highly enough. Since using this alongside Vegenac after having Covid, I’ve seen improvements in my health and heart. If you have long Covid, this is worth trying as it aids in breaking down the spike protein.
9
Stroke prevention
4 people found this helpful
Fibrinogen is crucial in blood clotting. Due to increased cases after the Covid vaccine, taking nattokinase is vital for preventing clots. For instance, after my mother had a stroke, three capsules daily helped decompose her brain clot, improving her cognitive recovery and preventing recurrence.
9
Aspirin alternative
6 people found this helpful
Nattokinase is a fantastic alternative to aspirin for preventing heart attacks. It has become essential in my medicine cabinet, and I highly recommend it for anyone concerned about thrombosis.
8
We designed a study to explore the effectiveness of nattokinase in treating acute myocardial infarction, a condition often caused by blood clots. Thrombus formation leads to reduced blood flow, and finding effective treatments is critical for improving outcomes in heart attack patients.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
Nattokinase is a naturally occurring enzyme known for its ability to dissolve blood clots, but its clinical use has been limited due to stability issues. To overcome this, we developed a manganese oxide nanozyme loaded with nattokinase, called MnOx@NK. This innovative approach not only delivers the clot-busting properties of nattokinase but also provides antioxidant benefits.
In our experiments using a mouse model of heart attack, we administered MnOx@NK through tail vein injections. The results were promising: we observed significant improvements in vascular function and a notable reduction in myocardial injury. The nanozyme effectively protected against oxidative stress, which can worsen the damage caused by heart attacks.
Overall, our findings suggest that using nattokinase-loaded nanozymes may pave the way for new treatments for acute myocardial infarction, potentially offering a safer and more effective option for patients facing this severe condition.
9.5
We aimed to explore the effectiveness of nattokinase, an enzyme with potent fibrinolytic properties, in treating heart attacks. Through our research, we focused on enhancing the production of nattokinase from a newly identified strain of Pseudomonas aeruginosa, referred to as CMSS, which we isolated from cow milk.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
Our comprehensive study involved optimizing different growth conditions such as pH, temperature, and nutrient sources, alongside improving the strain through UV-mutagenesis. We were excited to find that these optimizations led to a significant increase in nattokinase production.
The standout results showed that our modified strain produced nattokinase with a maximum activity of 4263 U mL(-1), which is double that of the original strain. In practical terms, this nattokinase achieved an impressive 94% blood clot lysis within ten minutes, hinting at its potential as a rapid acting treatment for heart-related issues.
Overall, our findings suggest that nattokinase from Pseudomonas aeruginosa CMSS could be a promising candidate for thrombolytic therapy, notably for those at risk of acute myocardial infarction. This unique study represents the first report of nattokinase production from this microorganism, opening the door to further research.
References
- Shi Y, Liu C, Gui Y, Guo Y, Zhang Y, et al. A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation. Adv Healthc Mater. 2024. doi:10.1002/adhm.202402763
- Chandrasekaran SD, Vaithilingam M, Shanker R, Kumar S, Thiyur S, et al. Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS. Jundishapur J Microbiol. 2015;8:e23567. doi:10.5812/jjm.23567
